Tag | Content |
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UniProt Accession | MK13_HUMAN; O15264; |
Entrez ID | 5603 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) |
Gene Name | MAPK13; PRKM13; SAPK4 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less s(view all) |
Sequence (Fasta) | MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF 60 QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM 120 EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT 180 GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 240 VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA 300 QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 360 SGMKL 366 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D002779 ; Cholestasis |
PTM | Modification Sites |
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Phosphorylation (count: 8) (view all) | 10 LIRKKGFYKQDVNKT dbPAF
180 RHADAEMTGYVVTRW dbPAF 182 ADAEMTGYVVTRWYR dbPAF 185 EMTGYVVTRWYRAPE dbPAF 350 YKEIVNFSPIARKDS dbPAF 357 SPIARKDSRRRSGMK dbPAF |
Ubiquitination (count: 2) | 165 VNEDCELKILDFGLA PLMD
226 GKTLFKGKDYLDQLT PLMD |