Tag | Content |
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UniProt Accession | IKKA_HUMAN; O15111; |
Entrez ID | 1147 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor k |
Gene Name | CHUK; IKKA; TCF16 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and a(view all) |
Sequence (Fasta) | MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH 60 EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120 ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS 180 FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240 CIFACEEMSG EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 300 FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 360 SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI 420 IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL 480 EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE 540 IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV 600 LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ 660 SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP QDGETSAQMI EENLNCLGHL 720 STIIHEANEE QGNSMMNLDW SWLTE 746 |
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Database | Annotation |
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CTD (Curated) (count: 7) (view all) | MESH:D000015
; Abnormalities, Multiple MESH:D001848 ; Bone Diseases, Developmental MESH:D002972 ; Cleft Palate OMIM:613630 ; COCOON SYNDROME MESH:D005315 ; Fetal Diseases MESH:D017880 ; Limb Deformities, Congenital |
DisGeNet (Curated) (count: 20) (view all) | C0005941; Bone Diseases, Developmental
C0008925; Cleft Palate C0015929; Fetal Diseases C0037268; Skin Abnormalities C0206762; Limb Deformities, Congenital C0241442; Protrusion of tongue |
GWASdb (count: 26) (view all) | rs11597086; Type 2 diabetes; type 2 diabetes mellitus
rs11597086; Multiple complex diseases; Null rs11597086; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs11597086; Fatty liver disease; fatty liver disease rs11597086; Alanine aminotransferase levels; fatty liver disease rs11597086; Fatty liver and alanine aminotransferase (ALT) levels; fatty liver disease |
PTM | Modification Sites |
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Phosphorylation (count: 12) (view all) | 123 LKESQILSLLSDIGS dbPAF
126 SQILSLLSDIGSGIR dbPAF 168 HKIIDLGYAKDVDQG dbPAF 176 AKDVDQGSLCTSFVG dbPAF 179 VDQGSLCTSFVGTLQ dbPAF 180 DQGSLCTSFVGTLQY dbPAF |
Acetylation (count: 2) | 569 QRAIDLYKQLKHRPS PLMD
645 TVMFMQGKRQKEIWH PLMD |
Ubiquitination (count: 12) (view all) | 105 CSGGDLRKLLNKPEN PLMD
109 DLRKLLNKPENCCGL PLMD 117 PENCCGLKESQILSL PLMD 139 IRYLHENKIIHRDLK PLMD 146 KIIHRDLKPENIVLQ PLMD 158 VLQDVGGKIIHKIID PLMD |
Malonylation (count: 1) | 425 LPIIQLRKVWAEAVH PLMD |