| Tag | Content |
|---|---|
| UniProt Accession | IKKB_HUMAN; O14920; |
| Entrez ID | 3551 |
| GenBank Protein ID | NM_001190720.2; NM_001242778.1; NM_001556.2; |
| GenBank Nucleotide ID | NP_001177649.1; NP_001229707.1; NP_001547.1; |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) |
| Gene Name | IKBKB; IKKB |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nu(view all) |
| Sequence (Fasta) | MSWSPSLTTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL 60 EIQIMRRLTH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG 120 AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL IHKIIDLGYA KELDQGSLCT 180 SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 240 VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPTYGPNGCF 300 KALDDILNLK LVHILNMVTG TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA 360 LIPDKPATQC ISDGKLNEGH TLDMDLVFLF DNSKITYETQ ISPRPQPESV SCILQEPKRN 420 LAFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK 480 AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA VELCGRENEV KLLVERMMAL 540 QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS 600 FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE KTVVRLQEKR QKELWNLLKI 660 ACSKVRGPVS GSPDSMNASR LSQPGQLMSQ PSTASNSLPE PAKKSEELVA EAHNLCTLLE 720 NAIQDTVREQ DQSFTALDWS WLQTEEEEHS CLEQAS 757 |
|
|||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | SMZL |
| CTD (Curated) (count: 2) | MESH:D006973
; Hypertension OMIM:615592 ; IMMUNODEFICIENCY 15 |
| DisGeNet (Curated) (count: 9) (view all) | C0001768; Agammaglobulinemia
C0021051; Immunologic Deficiency Syndromes C0035243; Respiratory Tract Infections C0231246; Failure to gain weight C0401151; Chronic diarrhea C1848924; Infantile onset |
| GWASdb (count: 5) | rs5029748; Atrial fibrillation; familial atrial fibrillation
rs17875677; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs4282553; Type 2 diabetes; type 2 diabetes mellitus rs11992861; Coronary artery calcification; coronary artery disease rs16891227; LDL cholesterol; atherosclerosis|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 62) (view all) | 169 HKIIDLGYAKELDQG dbPAF
177 AKELDQGSLCTSFVG dbPAF 180 LDQGSLCTSFVGTLQ dbPAF 181 DQGSLCTSFVGTLQY dbPAF 188 SFVGTLQYLAPELLE dbPAF 199 ELLEQQKYTVTVDYW dbPAF |
| Acetylation (count: 4) | 147 RIIHRDLKPENIVLQ PLMD
467 RNNSCLSKMKNSMAS PLMD 603 QAIQSFEKKVRVIYT PLMD 659 KELWNLLKIACSKVR PLMD |
| Ubiquitination (count: 10) (view all) | 106 CQGGDLRKYLNQFEN PLMD
147 RIIHRDLKPENIVLQ PLMD 163 GEQRLIHKIIDLGYA PLMD 301 YGPNGCFKALDDILN PLMD 337 DESLQSLKARIQQDT PLMD 418 SCILQEPKRNLAFFQ PLMD |
| Malonylation (count: 1) | 469 NSCLSKMKNSMASMS PLMD |