O14558

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession HSPB6_HUMAN; O14558;
Entrez ID 126393
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20)
Gene Name HSPB6
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSmall heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
Sequence
(Fasta)		MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL APYYLRAPSV 60
ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH ARHEERPDEH GFVAREFHRR 120
YRLPPGVDPA AVTSALSPEG VLSIQAAPAS AQAPPPAAAK 161

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDilated cardiomyopathyDS1618790732
[Reference]: In conclusion, we have identified a P20L substitution in human Hsp20, which is associated with diminished phosphorylation at Ser16 and complete abrogation of the Hsp20 cardioprotective effects which may adversely affect the ability of human carriers to cope with cellular stress.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D064420 ; Drug-Related Side Effects and Adverse Reactions
MESH:D006331 ; Heart Diseases
DisGeNet (Curated)
(count: 2)		C0018799; Heart Diseases
C0041755; Adverse reaction to drug

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 3)		 16        PSWLRRASAPLPGLS     dbPAF
59        PYYLRAPSVALPVAQ     dbPAF
84        LLDVKHFSPEEIAVK     dbPAF
Acetylation
(count: 1)		 160       APPPAAAK*******     PLMD