O08852

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	PKD1_MOUSE; O08852;
Entrez ID	18763
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein homolog)
Gene Name	Pkd1
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate. Functional Description Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Sequence (Fasta)	MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN CSGRWLQTLG 60 PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN NRISTLEEGV FANLFNLSEI 120 NLSGNPFECN CGLAWLPRWA KEHQVHVVQS EATTCRGPIP LAGQPLLSIP LLDNACGEEY 180 VACLPDNSSG AVAAVPFYFA HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS 240 SAACSSWCSS ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI 300 SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV QVEATPTVLE 360 LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ VVHPLCPLDT EIFPGNGHCY 420 RLVAEKAPWL QAQEQCRTWA GAALAMVDSP AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD 480 PRGEAFSLES CQNWLPGEPH PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT 540 ENFVMGMSGG GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE 600 PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP FDASCNSHVC 660 INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ DVPMLPGDLI GLQHDAGPGT 720 LLQCPLASSC PGQALYLSTN ASDWMTNLPV HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP 780 NPGLQHPGHY EVRATVGNSV SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV 840 LQVDSGANAT ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD 900 HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM VEAGSDVAFR 960 WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT VNYNVTVERM NKMHGLWVSA 1020 VPTVLPPNAT LALTGGVLVD SAVEVAFLWN FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL 1080 VEHNTTHIYT TPGEYNLTVL VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF 1140 SPYPLPSTDG VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI 1200 RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP EATVQHVYLR 1260 AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP TQPSAQLMAH VTGDPVHYLF 1320 DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP LALVLSSHVN KAHYFTSICV EPEIRNITLQ 1380 PERQFVKLGD EARLVAYSWP PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT 1440 VSNNISSTND SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS 1500 QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS RTVVPLNGSV 1560 SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT FNIIVTAENE VGSAQDSIFI 1620 YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA AVRDGTNISY SWTAQQEGSL ITLFGSGKCF 1680 SLTSLKASTY YVHLRATNML GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA 1740 GGSGVVYTWY LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG 1800 GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV RFSTAGSFSL 1860 QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP VHFEILLAAG SALTFRLQVG 1920 GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM 1980 ATGTEKNFTA RVQRGSRVAY AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN 2040 ELGGVNLTLM VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK 2100 TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA LPLQVLMRRS 2160 QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM VLPGVDVSRP QLVVPRLALP 2220 VGHYCFVFVV SFGDTPLARS IQANVTVAAE RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP 2280 NLEDGDQTPL NFHWACVAST QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK 2340 AGRKEEATNQ TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC 2400 WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS GEEEGCASIR 2460 LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG GAPLVYALLL KRCRQSYCEN 2520 FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV VQDQLGAAVV ALNRSLTIVL PEPSGNPADL 2580 VPWLHSLTAS VLPGLLKQAD PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN 2640 ITETLISLRV NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG 2700 TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL SSALMRILMR 2760 SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH FSIPEAFSGA LSNLSDVVQL 2820 IFLVDSNPFP FGYISNYTVS TKVASMAFQT QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ 2880 SSHNPVGSTI VQPQTSVSAV VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS 2940 VSQPNEYNCS ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV 3000 GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP PSHVQFIFPE 3060 PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV IPFCGKGGRF KYEILVKTGW 3120 SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR AFHRNSLDIF QIATPHSLGS VWKIRVWHDN 3180 KGLSPAWFLQ HIIVRDLQSA RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL 3240 LVAELQRGFF DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS 3300 MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT PTGQQALDVD 3360 SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC WPSSEGTLSW PDLLSDPSVV 3420 SSTLQRLTQG RPGCMLGSEE DGASLVSPSL PAKYLSASDE DLIHQVLADG ANNLVPTQDT 3480 LLETDLLTSL SSVPGEKTET LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL 3540 PAWCAPLAHG LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL 3600 EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE ARKVKRLHDM 3660 LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD SQAFLAITRS DEFWPWMSHV 3720 FLPYVHGNQS SPELGPPRLR QVRLQEAFCP DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN 3780 GSETWAYSAP DLLGAWYWGY CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV 3840 FVELTRYSPA VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF 3900 ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD RQWTHFVQDH 3960 PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR QWSVFGKTLC RALPELMGAT 4020 LGLVLLGVAY AQMAILLISS GADTLYNMAR AFLVLCPGAR VPTLCPSESW YLSPLLCVGL 4080 WALRVWGALR LGAILLRWRY HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR 4140 HKVRFEGMDP LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP 4200 EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP GCFPGSQPAL 4260 PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST 4294 Fasta Sequence >O08852\|Pkd1\|Mus musculus (Mouse) MPLGAPALLALALGLGLWLGALAGDPGRGCGPCPLPCFCGPAPDAACRVNCSGRWLQTLGPSLRIPADATALDLSHNLLQTLDIGLLVNLSALVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGLAWLPRWAKEHQVHVVQSEATTCRGPIPLAGQPLLSIPLLDNACGEEYVACLPDNSSGAVAAVPFYFAHEGPLETEACSAFCFSAGEGLAALSEQNQCLCGAGQASNSSAACSSWCSSISLSLNSACGGPTLLQHTFPASPGATLVGPHGPLASGQPADFHITSSLPISSTRWNFGDGSPEVDMASPAATHFYVLPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCPSFVHSNESLELGIRHRGGSALEVTYSILALDKEPAQVVHPLCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTWAGAALAMVDSPAIQHFLVSKVTRSLDVWIGFSSVEGTEGLDPRGEAFSLESCQNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVWDTENFVMGMSGGGLSGPLHPLAQQETVQGPLRPVEVMVFPGLSPSREAFLTAAEFSTQKLEEPAQMRLQVYRPSGGAAAVPEGSSEPDNRTEPAPKCVPEELWCPGANVCIPFDASCNSHVCINGSVSRLGLSRASYTLWKEFFFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPGTLLQCPLASSCPGQALYLSTNASDWMTNLPVHLEEAWAGPVCSLQLLLVTERLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIPLDGHIYVPTNGSVLVLQVDSGANATATAQWFGGNISAPFEDACPPEVDFLKQDCTEEANGTLFSVLMLPRLKEGDHTVEIVAQNGASQANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMVEAGSDVAFRWTIDDKQSLTFHNTVFNVIYQSAAIFKLSLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPTVLPPNATLALTGGVLVDSAVEVAFLWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYTTPGEYNLTVLVSNTYENLTQQVTVSVRTVLPNVAIGMSSNVLVAGQPITFSPYPLPSTDGVLYTWDFGDGSPVLIQSQPVLNHTYSMTGAYRITLEVNNTVSSVTAHADIRVFQELHGLTVYLSPSVEQGAPMVVSASVESGDNITWTFDMGDGTVFTGPEATVQHVYLRAQNFTVTVEAANPAGHLSQSLHVQVFVLEVLHIEPSTCIPTQPSAQLMAHVTGDPVHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVNKAHYFTSICVEPEIRNITLQPERQFVKLGDEARLVAYSWPPFPYRYTWDFGTEDTTHTQTGGSEVKFIYREPGSYLVIVTVSNNISSTNDSAFVEVQEPVLVTGIRINGSHVLELQQPYLLSAMGSGSPATYLWELGDGSQSEGPEVTHIYSSTGDFTVRVSGWNEVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFIYVLQFIEGLQVAGGDNGCCFPTNYTLQLQAAVRDGTNISYSWTAQQEGSLITLFGSGKCFSLTSLKASTYYVHLRATNMLGSAAANRTIDFVEPVESLILSASPNPAAVNMSLTLCAELAGGSGVVYTWYLEEGLSWKTSMPSTTHTFAAPGLHLVRVTAENQLGSVNATVEVAIQVPVGGLSIRTSEPDSIFVAAGSTLPFWGQLAEGTNVTWCWTLPGGSKDSQYIAVRFSTAGSFSLQLNASNAVSWVSAMYNLTVEEPIVNLMLWASSKVVAPGQPVHFEILLAAGSALTFRLQVGGSVPEVLPSPHFSHSFFRVGDHLVNVQAENHVSHAQAQVRILVLEAVVGLQVPNCCEPGMATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNLTLMVEVQDIIQYVTLQSGRCFTNRSARFEAATSPSPRRVTYHWDFGDGTPVQKTEEFWADHYYLRPGDYHVEVNATNLVSFFVAQATVTVQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEIYRTASCQRPGRMAQMVLPGVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLEDGDQTPLNFHWACVASTQSETGGCVLNFGPRGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGHCHNCSRGYKQGCWAARTFSNKTLVLNETTTSTGSTGMNLVVRPGALRDGEGYIFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLDSVRGLTTKVHFECTGWRDAEDGGAPLVYALLLKRCRQSYCENFCIYKGSLSTYGAVLPPGFQPLFVVSLAVVVQDQLGAAVVALNRSLTIVLPEPSGNPADLVPWLHSLTASVLPGLLKQADPQHVIEYSLALITVLNEYEQAPDVSEPNVEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILNITGDLIHLASLDMQGPQPLELGVEPPSLMVASKAYNLSSALMRILMRSRVLNEEPLTLAGEEIVALGKRSDPLSLLCYGKALGPSCHFSIPEAFSGALSNLSDVVQLIFLVDSNPFPFGYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHNPVGSTIVQPQTSVSAVVTADNSNPQAGLHLRITYTVLNERYLSAEPEPYLAVYLHSVSQPNEYNCSASRRISLEVLEGADHRLYTFFIAPGTGTLDRSYYLNLTSHFHWSALEVSVGLYTSLCQYFSEEMMMWRTEGIVPLEETSPSQAVCLTRHLTAFGASLFVPPSHVQFIFPEPSASINYIVLLTCVICLVTYVVMAMILRKLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGIMLYGEDNRSGHRHLDGDRAFHRNSLDIFQIATPHSLGSVWKIRVWHDNKGLSPAWFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRVQRVTCCVLLLCLFLAANAVWYGVVRDTTYSMGPVSSLISPGVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPTGQQALDVDSYLDPSVLDSSLLTLSGLTEAFAGQVKNDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVVSSTLQRLTQGRPGCMLGSEEDGASLVSPSLPAKYLSASDEDLIHQVLADGANNLVPTQDTLLETDLLTSLSSVPGEKTETLILQTVGEERPASMGLSWEQSPVTRLSRTGLVEGFQKRLLPAWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSERVPRVRPPHGFALFLAKEEARKVKRLHDMLKRLLVYMLFLLVTLLANYGDASCHGHAYRLQSAIKQELDSQAFLAITRSDEFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSEHMCSAAGSLSTSDYGIGWQSVVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVCLLLFALYFSMAEVQTWRKDGCACTARPDTWARCLLVILTAATGLVRLAQLGIADRQWTHFVQDHPRHFTSFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCPGARVPTLCPSESWYLSPLLCVGLWALRVWGALRLGAILLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTSSSQPDGPSASLSRSTLKLEPEPSRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLQGHGHNGPPSSPSPGCFPGSQPALPSRLSRASQGLDQTVGPNRVSLWPNNKVHPSST

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Autosomal-dominant polycystic kidney disease		C		23778143
1	[Reference]: we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleotide-dependent (NAD-dependent)?protein?deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of ADPKD. SIRT1 was upregulated through c-MYC in embryonic and postnatal Pkd1-mutant mouse renal epithelial cells and tissues and could be induced by TNF-, which is present in cyst fluid during cyst development.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 4)	MESH:D003560 ; Cysts MESH:D004195 ; Disease Models, Animal MESH:D016891 ; Polycystic Kidney, Autosomal Dominant MESH:D007690 ; Polycystic Kidney Diseases

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 5)	2333 LEAGVEYTFNLIVWK dbPAF 2715 ADSILNITGDLIHLA dbPAF 2808 FSIPEAFSGALSNLS dbPAF 3623 EDDTLVESPAVTPVS dbPAF 4159 PSRSSRGSKSSPVVL dbPAF

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O08852	P05784	MINT
O08852	P11679	MINT
O08852	Q3V1K9	MINT
O08852	Q5FWJ3	MINT
O08852	Q7TT18	MINT