O00767

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	ACOD_HUMAN; O00767;
Entrez ID	6319
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) (hSCD1)
Gene Name	SCD
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Functional Description Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Sequence (Fasta)	MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI KDDIYDPTYK 60 DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT WLWGVFYYFV SALGITAGAH 120 RLWSHRSYKA RLPLRLFLII ANTMAFQNDV YEWARDHRAH HKFSETHADP HNSRRGFFFS 180 HVGWLLVRKH PAVKEKGSTL DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE 240 TFQNSVFVAT FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY 300 HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR TGDGNYKSG 360 Fasta Sequence >O00767\|SCD\|Homo sapiens (Human) MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Tyrosine Phosphorylation	Non-small cell lung cancer/carcinoma		U	Y55	28724430
1	[Reference]: Ourstudy demonstrates that EGFR stabilizes SCD1 through Y55 phosphorylation, thereby up-regulating MUFA synthesis to promote lung cancer growth.We also propose SCD1 Y55 phosphorylation as a potential diagnostic marker for lung cancer.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 7) (view all)	MESH:D002277 ; Carcinoma MESH:D006528 ; Carcinoma, Hepatocellular MESH:D049970 ; Graves Ophthalmopathy MESH:D008064 ; Lipidoses MESH:D008113 ; Liver Neoplasms MESH:D015674 ; Mammary Neoplasms, Animal MESH:D008325 ; Mammary Neoplasms, Experimental
GWASdb (count: 1)	rs3978768; Depression (quantitative trait); mental depression

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 12) (view all)	14 QDDISSSYTTTTTIT dbPAF 198 PAVKEKGSTLDLSDL dbPAF 199 AVKEKGSTLDLSDLE dbPAF 203 KGSTLDLSDLEAEKL dbPAF 351 ILARIKRTGDGNYKS dbPAF 41 KLETMPLYLEDDIRP dbPAF 55 PDIKDDIYDPTYKDK dbPAF 59 DDIYDPTYKDKEGPS dbPAF 71 GPSPKVEYVWRNIIL dbPAF 80 WRNIILMSLLHLGAL dbPAF 91 LGALYGITLIPTCKF dbPAF 95 YGITLIPTCKFYTWL dbPAF
Ubiquitination (count: 14) (view all)	162 RDHRAHHKFSETHAD PLMD 189 VGWLLVRKHPAVKEK PLMD 194 VRKHPAVKEKGSTLD PLMD 196 KHPAVKEKGSTLDLS PLMD 209 LSDLEAEKLVMFQRR PLMD 337 LGLAYDRKKVSKAAI PLMD 338 GLAYDRKKVSKAAIL PLMD 34 VLQNGGDKLETMPLY PLMD 341 YDRKKVSKAAILARI PLMD 357 RTGDGNYKSG***** PLMD 51 DDIRPDIKDDIYDPT PLMD 60 DIYDPTYKDKEGPSP PLMD 62 YDPTYKDKEGPSPKV PLMD 68 DKEGPSPKVEYVWRN PLMD
Malonylation (count: 1)	341 YDRKKVSKAAILARI PLMD