O00622

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	CYR61_HUMAN; O00622;
Entrez ID	3491
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Protein CYR61 (CCN family member 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein GIG1)
Gene Name	CYR61; CCN1; GIG1; IGFBP10
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Functional Description Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Sequence (Fasta)	MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 60 NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 120 CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG 180 KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 240 KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300 AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 360 HANEAAFPFY RLFNDIHKFR D 382 Fasta Sequence >O00622\|CYR61; CCN1; GIG1; IGFBP10\|Homo sapiens (Human) MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Brain cancer/tumor		P		15026334
1	[Reference]: Furthermore, forced expression of Cyr61 in the glioma cells activated phosphatidylinositol 3'-kinase pathway, resulting in prominent phosphorylation of Akt and the antiapoptotic protein Bad.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 2)	MESH:D001172 ; Arthritis, Rheumatoid MESH:D006528 ; Carcinoma, Hepatocellular
DisGeNet (Curated) (count: 2)	C0003873; Rheumatoid Arthritis C2239176; Liver carcinoma

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 7) (view all)	14 RALALVVTLLHLTRL dbPAF 221 GMEPRILYNPLQGQK dbPAF 277 RPCGQPVYSSLKKGK dbPAF 278 PCGQPVYSSLKKGKK dbPAF 370 NEAAFPFYRLFNDIH dbPAF 84 ECNFGASSTALKGIC dbPAF 85 CNFGASSTALKGICR dbPAF
Ubiquitination (count: 5)	203 NELIAVGKGSSLKRL PLMD 228 YNPLQGQKCIVQTTS PLMD 241 TSWSQCSKTCGTGIS PLMD 74 TQPCDHTKGLECNFG PLMD 88 GASSTALKGICRAQS PLMD