| Tag | Content |
|---|---|
| UniProt Accession | TRAF5_HUMAN; O00463; |
| Entrez ID | 7188 |
| GenBank Protein ID | NM_001033910.2; NM_001319207.1; NM_004619.3; NM_145759.2; XM_011509959.2; XM_011509960.2; XM_017002221.1; |
| GenBank Nucleotide ID | NP_001029082.1; NP_001306136.1; NP_004610.1; NP_665702.1; XP_011508261.1; XP_011508262.1; XP_016857710.1; |
| Protein Name | TNF receptor-associated factor 5 (RING finger protein 84) |
| Gene Name | TRAF5; RNF84 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. |
| Sequence (Fasta) | MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 60 GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 120 ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL 180 QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ 240 HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG 300 KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE 360 NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA 420 VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ 480 RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD 540 DTLFLKVAVD LTDLEDL 558 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 20) (view all) | rs12723208; Glioma (high-grade); brain glioma
rs12723208; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis rs12723208; Methotrexate clearance (acute lymphoblastic leukemia); acute lymphocytic leukemia|acute leukemia rs2280079; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis rs2280079; Methotrexate clearance (acute lymphoblastic leukemia); acute lymphocytic leukemia|acute leukemia rs4951522; Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months); rheumatoid arthritis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 2) | 19 CGFIRQNSGNSISLD dbPAF
22 IRQNSGNSISLDFEP dbPAF |
| Ubiquitination (count: 17) (view all) | 100 VFKDNCCKREVLNLY PLMD
154 PVLRKDLKEHLSASC PLMD 234 YGCAVTDKRRNLQQH PLMD 256 HMRLVLEKNVQLEEQ PLMD 293 KKLEKEFKQFAQLFG PLMD 353 MEAVDTVKQKITLLE PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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