| Tag | Content |
|---|---|
| UniProt Accession | WASL_HUMAN; O00401; |
| Entrez ID | 8976 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Neural Wiskott-Aldrich syndrome protein (N-WASP) |
| Gene Name | WASL |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). |
| Sequence (Fasta) | MSSVQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA ADRNCMWSKK 60 CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY NSPRGYFHTF AGDTCQVALN 120 FANEEEAKKF RKAVTDLLGR RQRKSEKRRD PPNGPNLPMA TVDIKNPEIT TNRFYGPQVN 180 NISHTKEKKK GKAKKKRLTK ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG 240 ISEAQLKDRE TSKVIYDFIE KTGGVEAVKN ELRRQAPPPP PPSRGGPPPP PPPPHNSGPP 300 PPPARGRGAP PPPPSRAPTA APPPPPPSRP SVAVPPPPPN RMYPPPPPAL PSSAPSGPPP 360 PPPSVLGVGP VAPPPPPPPP PPPGPPPPPG LPSDGDHQVP TTAGNKAALL DQIREGAQLK 420 KVEQNSRPVS CSGRDALLDQ IRQGIQLKSV ADGQESTPPT PAPTSGIVGA LMEVMQKRSK 480 AIHSSDEDED EDDEEDFEDD DEWED 506 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D056486 ; Chemical and Drug Induced Liver Injury |
| GWASdb (count: 3) | rs7776792; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease
rs9649465; Migraine; migraine rs2267875; Information processing speed; cognitive disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 100 ELYNNFVYNSPRGYF dbPAF
102 YNNFVYNSPRGYFHT dbPAF 135 KKFRKAVTDLLGRRQ dbPAF 171 IKNPEITTNRFYGPQ dbPAF 175 EITTNRFYGPQVNNI dbPAF 183 GPQVNNISHTKEKKK dbPAF |
| Malonylation (count: 1) | 132 EEAKKFRKAVTDLLG PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |